Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 13/20 | 0.40 |
| ▸ | PPARA | Q07869 | 13/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972487 | 1.00 | SMN1; SMN2 (0.43) | SMN1; SMN2PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL3971122 | 0.90 | PPARG (0.48) | SMN1; SMN2PPARGPPARAL3MBTL1LMNA | |
| SCHEMBL11993106 | 0.88 | PPARG (0.46) | SMN1; SMN2PPARGPPARAKDM4EALDH1A1 | |
| SCHEMBL3972373 | 0.83 | PPARG (0.46) | SMN1; SMN2PPARGPPARAALDH1A1L3MBTL1 | |
| SCHEMBL3972769 | 0.80 | PPARG (0.48) | SMN1; SMN2PPARGPPARA | |
| SCHEMBL3973137 | 0.80 | SMN1; SMN2 (0.41) | SMN1; SMN2PPARGPPARAALDH1A1L3MBTL1 | |
| SCHEMBL3972905 | 0.78 | PPARG (0.54) | PPARGPPARA | |
| SCHEMBL3972082 | 0.76 | PTGDR2 (0.40) | PPARGPPARAALDH1A1L3MBTL1LMNA | |
| SCHEMBL3979354 | 0.74 | PPARG (0.46) | SMN1; SMN2PPARGPPARAL3MBTL1LMNA | |
| SCHEMBL6903473 | 0.73 | PPARG (0.44) | SMN1; SMN2PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412326-B1 | BUTYRIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |