Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PPARG | P37231 | 17/20 | 0.54 |
| ▸ | PPARA | Q07869 | 15/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP12 | P39900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969193 | 0.89 | PPARG (0.45) | NPC1RAB9APPARGPPARA | |
| SCHEMBL3971631 | 0.89 | PPARG (0.53) | NPC1RAB9APPARGPPARA | |
| SCHEMBL3971644 | 0.86 | PPARA (0.53) | PPARGPPARAMMP2MMP9MMP12 | |
| Pemaglitazar SCHEMBL29908544 | 0.86 | PPARG (0.56) | NPC1RAB9APPARGPPARA | |
| SCHEMBL11992997 | 0.86 | PPARG (0.43) | NPC1RAB9APPARGPPARA | |
| Pemaglitazar SCHEMBL3971148 | 0.86 | PPARG (0.56) | NPC1RAB9APPARGPPARA | |
| Pemaglitazar SCHEMBL3971139 | 0.86 | PPARG (0.56) | NPC1RAB9APPARGPPARA | |
| Pemaglitazar SCHEMBL3971735 | 0.86 | PPARG (0.56) | NPC1RAB9APPARGPPARA | |
| SCHEMBL3972373 | 0.85 | PPARG (0.46) | NPC1RAB9APPARGPPARA | |
| SCHEMBL3979354 | 0.85 | PPARG (0.46) | NPC1RAB9APPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1412326-B1 | BUTYRIC ACID DERIVATIVES | MERCK PATENT GMBH (DE) | 2012-08-22 | — | — | EP | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |
| US-7491747-B2 | 4-(Arylthio)- or (4-heteroarylthio)butyric acid derivatives that may be used in the treatment of dyslipidaemia, atherosclerosis and diabetes | MERCK PATENT GMBH (DE) | 2009-02-17 | — | — | US | disclosed |