Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 17/20 | 1.00 |
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11996042 | 1.00 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| SCHEMBL11996036 | 1.00 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| SCHEMBL16945694 | 1.00 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| SCHEMBL18025375 | 1.00 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| SCHEMBL11996038 | 1.00 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| SCHEMBL11996034 | 1.00 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL27165616 | 0.99 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| Hydrochloric Acid SCHEMBL27165704 | 0.99 | SPHK1 (1.00) | SPHK1SPHK2L3MBTL1 | |
| SCHEMBL18969864 | 0.89 | SPHK1 (0.80) | SPHK1SPHK2L3MBTL1 | |
| SCHEMBL18969861 | 0.89 | SPHK1 (0.80) | SPHK1SPHK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3223807-B1 | METHOD OF PREVENTING OR TREATING A PULMONARY DISEASE OR CONDITION | UNIV ILLINOIS (US) | 2021-09-15 | — | — | EP | disclosed |
| US-11026918-B2 | Method of preventing or treating a pulmonary disease or condition | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2021-06-08 | — | — | US | disclosed |
| US-20210040215-A1 | METHODS FOR ENHANCING THE POTENCY OF THE IMMUNE CHECKPOINT INHIBITORS | Université Toulouse III - Paul Sabatier (FR) | 2021-02-11 | — | — | US | disclosed |
| US-10822415-B2 | Methods for enhancing the potency of the immune checkpoint inhibitors | INSERM (INSTITUT NATIONAL DE LA SANTÉET DE LA RECHERCHE MÉDICALE) (FR) | 2020-11-03 | — | — | US | disclosed |
| US-20190031757-A1 | METHODS FOR ENHANCING THE POTENCY OF THE IMMUNE CHECKPOINT INHIBITORS | INSERM (Institut National de la Santé et de la Recherche Médicale (FR) | 2019-01-31 | — | — | US | disclosed |
| US-9908849-B2 | Imidamide sphingosine kinase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-03-06 | — | — | US | disclosed |
| US-9908849-B2 | Imidamide sphingosine kinase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2018-03-06 | — | — | US | disclosed |
| US-20170360749-A1 | METHOD OF PREVENTING OR TREATING A PULMONARY DISEASE OR CONDITION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-12-21 | — | — | US | disclosed |
| US-20170360749-A1 | METHOD OF PREVENTING OR TREATING A PULMONARY DISEASE OR CONDITION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-12-21 | — | — | US | disclosed |
| US-20170166525-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA | 2017-06-15 | — | — | US | disclosed |
| US-20170166525-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA | 2017-06-15 | — | — | US | disclosed |
| US-9421177-B2 | Imidamide sphingosine kinase inhibitors | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2016-08-23 | — | — | US | disclosed |
| WO-2016085933-A1 | METHOD OF PREVENTING OR TREATING A PULMONARY DISEASE OR CONDITION | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-06-02 | — | — | WO | disclosed |
| US-20120214858-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-08-23 | — | — | US | disclosed |
| WO-2011020116-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-02-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190031757-A1 | METHODS FOR ENHANCING THE POTENCY OF THE IMMUNE CHECKPOINT INHIBITORS | CD274, PDCD1, PDCD1LG2 | SPHK1 96/4885SPHK2 270/4885L3MBTL1 2193/4885 |
| US-11026918-B2 | Method of preventing or treating a pulmonary disease or condition | SPHK1, SPHK2, SMPD3 | SPHK1 1/4885SPHK2 2/4885L3MBTL1 4037/4885 |
| US-20170360749-A1 | METHOD OF PREVENTING OR TREATING A PULMONARY DISEASE OR CONDITION | SPHK1, SPHK2, SMPD3 | SPHK1 1/4885SPHK2 2/4885L3MBTL1 4037/4885 |
| US-20210040215-A1 | METHODS FOR ENHANCING THE POTENCY OF THE IMMUNE CHECKPOINT INHIBITORS | CD274, PDCD1, PDCD1LG2 | SPHK1 96/4885SPHK2 270/4885L3MBTL1 2193/4885 |
| US-10822415-B2 | Methods for enhancing the potency of the immune checkpoint inhibitors | CD274, PDCD1, PDCD1LG2 | SPHK1 96/4885SPHK2 270/4885L3MBTL1 2193/4885 |
| US-20120214858-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | SPHK2, SPHK1, S1PR2 | SPHK1 2/4885SPHK2 1/4885L3MBTL1 2676/4885 |
| US-20170166525-A1 | IMIDAMIDE SPHINGOSINE KINASE INHIBITORS | SPHK2, SPHK1, S1PR2 | SPHK1 2/4885SPHK2 1/4885L3MBTL1 2676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.