Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE9A | O76083 | 6/20 | 0.49 |
| ▸ | B3GNT2 | Q9NY97 | 2/20 | 0.46 |
| ▸ | PDE5A | O76074 | 4/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE6D | O43924 | 1/20 | 0.35 |
| ▸ | PDE8A | O60658 | 1/20 | 0.35 |
| ▸ | PDE8B | O95263 | 1/20 | 0.35 |
| ▸ | PDE6A | P16499 | 1/20 | 0.35 |
| ▸ | PDE6G | P18545 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE6B | P35913 | 1/20 | 0.35 |
| ▸ | PDE6C | P51160 | 1/20 | 0.35 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591900 | 0.90 | PDE9A (0.47) | PDE9AB3GNT2PDE5AHCAR3PDE2A | |
| SCHEMBL3590878 | 0.86 | PDE9A (0.49) | PDE9AB3GNT2PDE5AHCAR3PDE2A | |
| SCHEMBL3591653 | 0.78 | PDE9A (0.45) | PDE9APDE5AALDH1A1KMT2APARP1 | |
| SCHEMBL3597406 | 0.78 | PDE9A (0.77) | PDE9AB3GNT2PDE5AHCAR3AURKA | |
| SCHEMBL3592193 | 0.77 | PDE9A (0.60) | PDE9AB3GNT2PDE5AHCAR3PDE2A | |
| SCHEMBL3593100 | 0.76 | PDE9A (0.45) | PDE9APDE5AALDH1A1KMT2APARP1 | |
| SCHEMBL3598136 | 0.74 | PDE9A (0.66) | PDE9AB3GNT2PDE5APDE2APDE6D | |
| SCHEMBL3593207 | 0.74 | PDE9A (0.46) | PDE9APDE5AALDH1A1KMT2APARP1 | |
| SCHEMBL3587004 | 0.74 | PDE9A (0.53) | PDE9APDE5APDE2APDE6DPDE8A | |
| SCHEMBL3602977 | 0.73 | PDE9A (0.48) | PDE9APDE5AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2489667-A1 | Quinoxaline derivative | ASKA Pharmaceutical Co., Ltd. (JP) | 2012-08-22 | — | — | EP | disclosed |