Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10058500 | 0.92 | PTGER4 (0.48) | PTGER4SMN1; SMN2CYP1A2CYP2D6PKM | |
| SCHEMBL12002044 | 0.89 | PTGER4 (0.41) | PTGER4SMN1; SMN2CYP1A2CYP2D6PKM | |
| SCHEMBL9606782 | 0.89 | PTGER4 (0.54) | PTGER4SMN1; SMN2CYP1A2CYP2D6PKM | |
| SCHEMBL12002249 | 0.89 | PTGER4 (0.45) | PTGER4SMN1; SMN2CYP1A2CYP2D6PKM | |
| SCHEMBL12002087 | 0.87 | PTGER4 (0.43) | PTGER4SMN1; SMN2CYP1A2CYP2D6PKM | |
| SCHEMBL10058526 | 0.86 | PTGER4 (0.56) | PTGER4CYP1A2CYP2D6PKM | |
| SCHEMBL10058533 | 0.85 | PTGER4 (0.49) | PTGER4SMN1; SMN2CYP1A2CYP2D6PKM | |
| SCHEMBL14431077 | 0.85 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6ALDH1A1 | |
| SCHEMBL14431119 | 0.84 | PTGER4 (0.49) | PTGER4SMN1; SMN2CYP1A2CYP2D6RECQL | |
| SCHEMBL10058532 | 0.84 | PTGER4 (0.45) | PTGER4SMN1; SMN2CYP1A2CYP2D6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1979317-B1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LTD (GB) | 2012-08-22 | — | — | EP | disclosed |
| WO-2007088189-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2007-08-09 | — | — | WO | disclosed |