Known targets — ChEMBL curated mechanism
FGFR3FLT1FLT3FLT4KDRKITPDGFRAPDGFRB
The experimentally established mechanism targets of Dovitinib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB known ✓ | P09619 | 17/20 | 0.85 |
| ▸ | KDR known ✓ | P35968 | 17/20 | 0.85 |
| ▸ | FLT1 known ✓ | P17948 | 4/20 | 0.85 |
| ▸ | FLT3 known ✓ | P36888 | 2/20 | 0.85 |
| ▸ | KIT known ✓ | P10721 | 1/20 | 0.85 |
| ▸ | PDGFRA known ✓ | P16234 | 1/20 | 0.85 |
| ▸ | FGFR3 known ✓ | P22607 | 1/20 | 0.85 |
| ▸ | FLT4 known ✓ | P35916 | 1/20 | 0.85 |
| ▸ | FGFR1 | P11362 | 19/20 | 0.85 |
| ▸ | LCK | P06239 | 2/20 | 0.85 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.85 |
| ▸ | PLK4 | O00444 | 1/20 | 0.85 |
| ▸ | STK25 | O00506 | 1/20 | 0.85 |
| ▸ | CIT | O14578 | 1/20 | 0.85 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.85 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.85 |
| ▸ | GAK | O14976 | 1/20 | 0.85 |
| ▸ | CHUK | O15111 | 1/20 | 0.85 |
| ▸ | MUSK | O15146 | 1/20 | 0.85 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.85 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dovitinib SCHEMBL949705 | 0.99 | FGFR1 (0.86) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL30567813 | 0.99 | FGFR1 (0.86) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL248083 | 0.93 | FGFR1 (0.98) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL945391 | 0.93 | FGFR1 (0.73) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL29352967 | 0.92 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL172687 | 0.92 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL29424010 | 0.92 | FGFR1 (1.00) | FGFR1PDGFRBKDRFLT1LCK | |
| Dovitinib SCHEMBL946022 | 0.92 | FGFR1 (0.75) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL14818888 | 0.90 | FGFR1 (0.71) | FGFR1PDGFRBKDRFLT1LCK | |
| SCHEMBL24233174 | 0.89 | FGFR1 (0.71) | FGFR1PDGFRBKDRFLT1LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2309987-B1 | MELT GRANULATION PROCESS | NOVARTIS AG (CH) | 2012-08-29 | — | — | EP | claimed |