Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | VCP | P55072 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13819674 | 0.94 | MEN1 (0.33) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819677 | 0.89 | MEN1 (0.33) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819444 | 0.86 | MEN1 (0.34) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13766159 | 0.84 | ADORA2A (0.32) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819683 | 0.83 | MEN1 (0.30) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819288 | 0.82 | MEN1 (0.32) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819673 | 0.82 | MEN1 (0.32) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819686 | 0.82 | MEN1 (0.31) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819443 | 0.81 | MEN1 (0.32) | MEN1ALDH1A1LMNACYP3A4NFKB1 | |
| SCHEMBL13819681 | 0.81 | ACACB (0.32) | MEN1ALDH1A1LMNACYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8252767-B2 | Substituted 4-{3-[6-amino-9-(3, 4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists | DOGWOOD PHARMACEUTICALS, INC. (US) | 2012-08-28 | — | — | US | disclosed |