Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.75 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1372699 | 0.86 | HRH3 (1.00) | HRH3KCNH2ADRA2CSLC6A3 | |
| SCHEMBL1372701 | 0.86 | HRH3 (1.00) | HRH3KCNH2ADRA2CSLC6A3 | |
| SCHEMBL12017563 | 0.82 | HRH3 (0.98) | HRH3KCNH2ADRA2CSLC6A3GPR119 | |
| SCHEMBL11986395 | 0.82 | HRH3 (0.68) | HRH3KCNH2ADRA2CSLC6A3GPR119 | |
| SCHEMBL11372257 | 0.78 | HRH3 (0.63) | HRH3KCNH2ADRA2CSLC6A3GPR119 | |
| SCHEMBL11365959 | 0.74 | HRH3 (0.59) | HRH3KCNH2ADRA2CSLC6A3 | |
| SCHEMBL1373531 | 0.73 | HRH3 (1.00) | HRH3KCNH2ADRA2CSLC6A3 | |
| SCHEMBL1373529 | 0.73 | HRH3 (1.00) | HRH3KCNH2ADRA2CSLC6A3 | |
| SCHEMBL11986394 | 0.73 | HRH3 (0.69) | HRH3KCNH2ADRA2CSLC6A3GPR119 | |
| SCHEMBL10267647 | 0.71 | HRH3 (0.66) | HRH3KCNH2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502918-A1 | Pyridizinone Derivatives | Cephalon, Inc. (US) | 2012-09-26 | — | — | EP | disclosed |
| EP-2492263-A1 | Pyridizinone Derivatives | Cephalon, Inc. (US) | 2012-08-29 | — | — | EP | disclosed |