Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 14/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12014183 | 0.95 | EGLN1 (0.41) | EGLN1ALDH1A1 | |
| SCHEMBL12002622 | 0.94 | EGLN1 (0.49) | EGLN1 | |
| SCHEMBL12781814 | 0.87 | EGLN1 (0.32) | EGLN1 | |
| SCHEMBL12602155 | 0.87 | EGLN1 (0.43) | EGLN1KDM4EALDH1A1HSD17B10BDKRB1 | |
| SCHEMBL12014181 | 0.84 | EGLN1 (0.42) | EGLN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL12014186 | 0.84 | EGLN1 (0.38) | EGLN1KDM4EALDH1A1HSD17B10 | |
| SCHEMBL12002624 | 0.84 | EGLN1 (0.45) | EGLN1 | |
| SCHEMBL12602076 | 0.83 | EGLN1 (0.49) | EGLN1ALDH1A1 | |
| SCHEMBL12002683 | 0.83 | EGLN1 (0.51) | EGLN1 | |
| SCHEMBL1772645 | 0.82 | EGLN1 (0.52) | EGLN1MAPTCHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2492266-A1 | 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE DERIVATIVE | Daiichi Sankyo Company, Limited (JP) | 2012-08-29 | — | — | EP | disclosed |