Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 7/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 7/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 7/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 7/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1203002 | 0.92 | PTPN11 (0.44) | PTPN11GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL3793530 | 0.78 | PTPN11 (0.58) | PTPN11GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL1203484 | 0.78 | DDR2 (0.44) | SMN1; SMN2KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL14897368 | 0.74 | IRAK4 (0.46) | SMN1; SMN2ALDH1A1POLBMAPTNPC1 | |
| SCHEMBL14896979 | 0.74 | IRAK4 (0.49) | SMN1; SMN2ALDH1A1RAB9AIRAK4 | |
| SCHEMBL1202738 | 0.74 | IRAK4 (0.41) | SMN1; SMN2ALDH1A1POLBMAPTIRAK4 | |
| SCHEMBL1203470 | 0.74 | KCNQ3 (0.46) | SMN1; SMN2KDM4EALDH1A1POLBNPC1 | |
| SCHEMBL1202894 | 0.73 | CYP3A4 (0.49) | SMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL1203606 | 0.73 | FYN (0.59) | — | |
| SCHEMBL1202745 | 0.73 | MKNK1 (0.56) | KDM4EALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-02-24 | — | — | US | disclosed |
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046127-A1 | Imidazopyridazines for Use as Protein Kinase Inhibitors | PIM1, PIM3, PIM2 | PTPN11 971/4885GRIN2D 3722/4885GRIN3B 4203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.