Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.60 |
| ▸ | KCNMA1 | Q12791 | 4/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16235767 | 0.83 | APP (0.69) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL16235764 | 0.83 | APP (0.69) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL27599839 | 0.82 | APP (0.65) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL10712446 | 0.81 | MAPT (0.64) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL13379289 | 0.80 | APP (0.66) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL6348671 | 0.79 | APP (0.58) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL9365281 | 0.79 | APP (0.58) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL1503974 | 0.79 | APP (0.60) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL3308366 | 0.79 | APP (0.64) | APPKCNMA1TRPV1PKML3MBTL1 | |
| SCHEMBL3308373 | 0.79 | APP (0.64) | APPKCNMA1TRPV1PKML3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110312990-A1 | Diamine Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-12-22 | — | — | US | disclosed |
| US-20110077266-A1 | Diamine Derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2011-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077266-A1 | Diamine Derivatives | F2, TFPI, F3 | APP 1695/4885KCNMA1 3520/4885TRPV1 2930/4885 |
| US-20110312990-A1 | Diamine Derivatives | C9, C1S, C1R | APP 3696/4885KCNMA1 2011/4885TRPV1 2036/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.