Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16441086 | 0.94 | FOLH1 (0.32) | SIRT2SIRT1 | |
| SCHEMBL277717 | 0.85 | SIRT2 (0.35) | SIRT2SIRT1KLK7KLK5 | |
| SCHEMBL12038022 | 0.83 | SIRT2 (0.40) | SIRT2SIRT1 | |
| SCHEMBL13311706 | 0.81 | SIRT2 (0.34) | SIRT2SIRT1KLK7KLK5 | |
| SCHEMBL12417528 | 0.81 | FOLH1 (0.33) | SIRT2SIRT1KLK7KLK5 | |
| SCHEMBL12692608 | 0.80 | FOLH1 (0.36) | SIRT2SIRT1 | |
| SCHEMBL14753625 | 0.79 | FOLH1 (0.34) | SIRT2SIRT1KLK7KLK5 | |
| SCHEMBL16441084 | 0.78 | SIRT2 (0.36) | SIRT2SIRT1 | |
| SCHEMBL13339580 | 0.78 | SIRT2 (0.36) | SIRT2SIRT1KLK7KLK5 | |
| SCHEMBL277487 | 0.77 | SIRT2 (0.40) | SIRT2SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110318322-A1 | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer | NEKTAR THERAPEUTICS (US) | 2011-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110318322-A1 | Conjugates of a Lysosomal Enzyme Moiety and a Water Soluble Polymer | GAA, MAN2B1, GBA1 | SIRT2 3364/4885SIRT1 3115/4885KLK7 1555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.