SCHEMBL12038136

SCHEMBL12038136

Cc1nc(N)nc(NCO)n1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.38
HSP90AB1 P08238 1/20 0.38
GAA P10253 4/20 0.36
HRH4 Q9H3N8 1/20 0.35
TLR8 Q9NR97 1/20 0.34
TLR7 Q9NYK1 1/20 0.34
MEN1 O00255 3/20 0.33
KMT2A Q03164 3/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
MAPK1 P28482 1/20 0.33
ALDH1A1 P00352 1/20 0.33
GPR68 Q15743 2/20 0.33
ADORA2A P29274 1/20 0.33
HTR2B P41595 1/20 0.33
MCL1 Q07820 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
KDM4E B2RXH2 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23095331 0.90 GAA (0.37) HSP90AA1HSP90AB1GAATLR8TLR7
SCHEMBL23095371 0.85 TLR8 (0.39) HSP90AA1GAATLR8TLR7MEN1
Ethane SCHEMBL8201842 0.85 CA1 (0.38) HSP90AA1GAAHRH4MEN1KMT2A
Methyl Alcohol SCHEMBL736036 0.85 CA1 (0.38) HSP90AA1GAAHRH4MEN1KMT2A
SCHEMBL63021 0.84 MCL1 (0.38) GAATLR8TLR7MEN1KMT2A
SCHEMBL13216046 0.84 GAA (0.41) GAAMEN1KMT2AMAPK1MCL1
SCHEMBL66618 0.84 CA1 (0.40) GAAMEN1KMT2ASMN1; SMN2MAPK1
SCHEMBL11594242 0.84 CA1 (0.40) GAAMEN1KMT2ASMN1; SMN2MAPK1
SCHEMBL14389373 0.84 KMT2A (0.52) HSP90AA1GAAHRH4TLR8TLR7
Alcohol SCHEMBL5090035 0.83 MEN1 (0.38) HSP90AA1GAATLR8TLR7MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9063447-B2 Imaging members having a cross-linked anticurl back coating XEROX CORPORATION (US) 2015-06-23 US disclosed
US-9017906-B2 Imaging members having a cross-linked anticurl back coating XEROX CORPORATION (US) 2015-04-28 US disclosed
US-8394560-B2 Imaging members having an enhanced charge blocking layer XEROX CORPORATION (US) 2013-03-12 US disclosed
US-20110318675-A1 IMAGING MEMBERS HAVING AN ENHANCED CHARGE BLOCKING LAYER XEROX CORPORATION (US) 2011-12-29 US disclosed