⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Saprisartan SCHEMBL29813295 | 1.00 | — | — | |
| Saprisartan SCHEMBL588531 | 0.99 | — | — | |
| SCHEMBL8544117 | 0.97 | — | — | |
| SCHEMBL8957327 | 0.94 | — | — | |
| SCHEMBL8548685 | 0.93 | — | — | |
| SCHEMBL8546004 | 0.93 | — | — | |
| SCHEMBL8957280 | 0.92 | — | — | |
| SCHEMBL8544800 | 0.92 | — | — | |
| SCHEMBL8542117 | 0.92 | — | — | |
| SCHEMBL9616353 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1838 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250082608-A1 | TREATMENT AND PREVENTION OF GLOMERULAR DISEASE | SINGAPORE HEALTH SERVICES PTE LTD. (SG) | 2025-03-13 | — | — | US | claimed |
| CN-113056465-B | Tetrahydropyrane (THP) -substituted bicyclic pyrimidinedione compounds | 迈奥卡迪亚公司 | 2025-01-28 | — | — | CN | claimed |
| US-20240358731-A1 | SUMO PATHWAY AS AN OXYGEN SENSOR RELEVANT TO THE PATHOPHYSIOLOGY OF PULMONARY ARTERY HYPERTENSION AND CARDIAC ARRHYTHMIA | NORTHEASTERN UNIVERSITY | 2024-10-31 | — | — | US | claimed |
| US-20240358727-A1 | MICROSCALE THERMOPHORESIS TO EVALUATE CHANNEL LIPID INTERACTIONS AND METHODS OF TREATING NAV CHANNELS RELATED DISEASES | NORTHEASTERN UNIVERSITY | 2024-10-31 | — | — | US | claimed |
| EP-4448096-A1 | TREATMENT AND PREVENTION OF GLOMERULAR DISEASE | Singapore Health Services Pte. Ltd. (SG) | 2024-10-23 | — | — | EP | claimed |
| US-20240300904-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | UNIVERSITETET I OSLO (NO) | 2024-09-12 | — | — | US | claimed |
| EP-3873904-B1 | TETRAHYDROPYRAN (THP)-SUBSTITUTED BICYCLIC-PYRIMIDINEDIONE COMPOUNDS | MYOKARDIA INC (US) | 2024-07-10 | — | — | EP | claimed |
| US-12016835-B2 | Neprilysin inhibitors | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2024-06-25 | — | — | US | claimed |
| EP-4351518-A1 | PYRIDAZINONES FOR THE TREATMENT OR PREVENTION OF HYPERTENSION | Universitetet I Oslo (NO) | 2024-04-17 | — | — | EP | claimed |
| US-11931341-B2 | Compositions and methods for the treatment and prevention of muscular dystrophy | UNIVERSITY OF LOWA RESEARCH FOUNDATION (US) | 2024-03-19 | — | — | US | claimed |
| CN-1192697-A | Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy for the treatment of congestive heart failure | SEARLE & CO (US) | 1998-09-09 | — | — | CN | claimed |
| EP-0514198-B1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LTD (GB) | 1998-08-05 | — | — | EP | claimed |
| EP-0831910-A1 | EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1998-04-01 | — | — | EP | claimed |
| EP-0831911-A2 | SPIRONOLACTONE AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040255-A2 | METHOD TO TREAT CARDIOFIBROSIS WITH A COMBINATION THERAPY OF AN ANGIOTENSIN II ANTAGONIST AND AN EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040257-A1 | EPOXY-STEROIDAL ALDOSTERONE ANTAGONIST AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040258-A2 | SPIRONOLACTONE AND ANGIOTENSIN II ANTAGONIST COMBINATION THERAPY FOR TREATMENT OF CONGESTIVE HEART FAILURE | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | claimed |
| WO-1996040256-A1 | METHOD TO TREAT CARDIOFIBROSIS WITH A COMBINATION OF AN ANGIOTENSIN II ANTAGONIST AND SPIRONOLACTONE | G.D. SEARLE & CO. (US) | 1996-12-19 | — | — | WO | claimed |
| US-5332831-A | Angiotensin antagonist | GLAXO GROUP LIMITED (GB) | 1994-07-26 | — | — | US | claimed |
| EP-0514198-A1 | 1H-Imidazol-1-yl-methyl benzofuran derivatives with the imidazolyl moiety being substituted by a cycloalkyl group | GLAXO GROUP LIMITED (GB) | 1992-11-19 | — | — | EP | claimed |