Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 19/20 | 0.67 |
| ▸ | DDB1 | Q16531 | 12/20 | 0.67 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.65 |
| ▸ | TNF | P01375 | 2/20 | 0.65 |
| ▸ | IL1B | P01584 | 1/20 | 0.65 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.65 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30566416 | 0.86 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24165659 | 0.86 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL29074089 | 0.86 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL30468711 | 0.86 | CRBN (0.66) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL22737366 | 0.85 | CRBN (0.67) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL15439893 | 0.85 | CRBN (0.67) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL24745183 | 0.85 | CRBN (0.65) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31077375 | 0.84 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL25278017 | 0.84 | CRBN (0.62) | CRBNDDB1IKZF3TNFIL1B | |
| SCHEMBL31444035 | 0.83 | CRBN (0.61) | CRBNDDB1IKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9193989-B2 | PRPK-TPRKB modulators and uses thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-11-24 | — | — | US | disclosed |
| US-9193989-B2 | PRPK-TPRKB modulators and uses thereof | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2015-11-24 | — | — | US | disclosed |
| US-20110319277-A1 | PRPK-TPRKB MODULATORS AND USES THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2011-12-29 | — | — | US | disclosed |
| US-20110319277-A1 | PRPK-TPRKB MODULATORS AND USES THEREOF | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2011-12-29 | — | — | US | disclosed |
| WO-2011160042-A2 | PRPK-TPRKB MODULATORS AND USES THEREOF | MAKOTO LIFE SCIENCES, INC. (US) | 2011-12-22 | — | — | WO | disclosed |