Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | BRAF | P15056 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 3/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | FLT1 | P17948 | 2/20 | 0.35 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12044072 | 1.00 | KDR (0.47) | KDRFGFR1BRAFNTRK1AURKB | |
| SCHEMBL12044091 | 0.94 | KDR (0.48) | KDRFGFR1BRAFAURKAKMT2A | |
| SCHEMBL12044369 | 0.89 | KDR (0.48) | KDRFGFR1BRAFNTRK1AURKB | |
| SCHEMBL12044224 | 0.89 | KDR (0.48) | KDRFGFR1BRAFNTRK1AURKB | |
| SCHEMBL3571783 | 0.87 | KDR (0.48) | KDRFGFR1BRAFNTRK1AURKB | |
| SCHEMBL12044108 | 0.87 | FGFR1 (0.40) | KDRFGFR1BRAFTLK2 | |
| SCHEMBL3571787 | 0.87 | KDR (0.48) | KDRFGFR1BRAFNTRK1AURKB | |
| SCHEMBL3580742 | 0.85 | KDR (0.51) | KDRFGFR1BRAFNTRK1AURKB | |
| SCHEMBL3580746 | 0.85 | KDR (0.51) | KDRFGFR1BRAFNTRK1AURKB | |
| SCHEMBL12044093 | 0.84 | KDR (0.39) | KDRFGFR1KMT2ATLK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8455529-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-8455529-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2013-06-04 | — | — | US | disclosed |
| US-20110319460-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-20110319460-A1 | KINASE INHIBITORS | ALLERGAN, INC. (US) | 2011-12-29 | — | — | US | disclosed |
| US-8034957-B2 | Kinase inhibitors | ALLERGAN, INC. (US) | 2011-10-11 | — | — | US | disclosed |
| US-20100168199-A1 | Kinase Inhibitors | ALLENGAN, INC. (US) | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168199-A1 | Kinase Inhibitors | ABL1, LCK, ERBB2 | KDR 226/4885FGFR1 171/4885BRAF 21/4885 |
| US-20110319460-A1 | KINASE INHIBITORS | ABL1, LCK, ERBB2 | KDR 226/4885FGFR1 171/4885BRAF 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.