⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12059223 | 0.83 | GRIA1 (0.30) | — | |
| SCHEMBL15354744 | 0.80 | GRIA1 (0.31) | — | |
| SCHEMBL24114371 | 0.80 | GRIA1 (0.31) | — | |
| SCHEMBL2233510 | 0.78 | — | — | |
| SCHEMBL19210806 | 0.78 | — | — | |
| SCHEMBL7355100 | 0.73 | — | — | |
| SCHEMBL597793 | 0.72 | — | — | |
| SCHEMBL19158064 | 0.72 | — | — | |
| SCHEMBL1704311 | 0.72 | GRIA1 (0.32) | — | |
| SCHEMBL15354739 | 0.72 | GRIA1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319378-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2011-12-29 | — | — | US | disclosed |