Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 20/20 | 0.80 |
| ▸ | JAK2 | O60674 | 7/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.61 |
| ▸ | LCK | P06239 | 1/20 | 0.61 |
| ▸ | LYN | P07948 | 1/20 | 0.61 |
| ▸ | RET | P07949 | 1/20 | 0.61 |
| ▸ | SRC | P12931 | 1/20 | 0.61 |
| ▸ | TEC | P42680 | 1/20 | 0.61 |
| ▸ | TXK | P42681 | 1/20 | 0.61 |
| ▸ | BLK | P51451 | 1/20 | 0.61 |
| ▸ | BMX | P51813 | 1/20 | 0.61 |
| ▸ | ITK | Q08881 | 1/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.61 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.61 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064377 | 0.89 | BTK (1.00) | BTKJAK2NTRK1LCKLYN | |
| SCHEMBL12064368 | 0.88 | BTK (1.00) | BTKJAK2NTRK1LCKLYN | |
| SCHEMBL12071530 | 0.83 | BTK (0.78) | BTKJAK2NTRK1LCKLYN | |
| SCHEMBL27982606 | 0.83 | BTK (0.77) | BTKJAK2NTRK1LCKLYN | |
| SCHEMBL28814642 | 0.80 | BTK (0.84) | BTKJAK2NTRK1LCKLYN | |
| SCHEMBL122422 | 0.80 | BTK (0.74) | BTKJAK2NTRK1LCKLYN | |
| SCHEMBL29782717 | 0.79 | BTK (1.00) | BTK | |
| SCHEMBL17699949 | 0.79 | BTK (1.00) | BTK | |
| SCHEMBL12071969 | 0.79 | BTK (0.60) | BTKJAK2NTRK1LCKLYN | |
| SCHEMBL27982114 | 0.78 | BTK (1.00) | BTKJAK2NTRK1LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8084620-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2011-12-27 | — | — | US | disclosed |