Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.78 |
| ▸ | JAK2 | O60674 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7459217 | 0.88 | LRRK2 (0.81) | LRRK2JAK2 | |
| SCHEMBL7453469 | 0.88 | LRRK2 (0.81) | LRRK2JAK2 | |
| SCHEMBL7450050 | 0.88 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL12066684 | 0.86 | LRRK2 (0.77) | LRRK2JAK2 | |
| SCHEMBL7457990 | 0.86 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL12066135 | 0.85 | LRRK2 (0.82) | LRRK2JAK2 | |
| SCHEMBL14556225 | 0.83 | LRRK2 (0.94) | LRRK2JAK2 | |
| SCHEMBL7456000 | 0.82 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL7445505 | 0.81 | LRRK2 (1.00) | LRRK2JAK2 | |
| SCHEMBL7451486 | 0.81 | LRRK2 (0.86) | LRRK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011151360-A1 | AMINOPYRIMIDINE DERIVATIVES AS LRRK2 MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-12-08 | — | — | WO | disclosed |