Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 19/20 | 0.83 |
| ▸ | JAK3 | P52333 | 19/20 | 0.83 |
| ▸ | JAK1 | P23458 | 13/20 | 0.83 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1693758 | 0.91 | JAK2 (0.84) | JAK2JAK3JAK1 | |
| SCHEMBL1694495 | 0.91 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1694497 | 0.91 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1694331 | 0.91 | JAK2 (0.83) | JAK2JAK3JAK1 | |
| SCHEMBL1694328 | 0.91 | JAK2 (0.83) | JAK2JAK3JAK1 | |
| SCHEMBL14849917 | 0.91 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1693019 | 0.90 | JAK2 (0.82) | JAK2JAK3JAK1 | |
| SCHEMBL1693649 | 0.90 | JAK2 (0.81) | JAK2JAK3JAK1 | |
| SCHEMBL1694324 | 0.89 | JAK2 (1.00) | JAK2JAK3JAK1 | |
| SCHEMBL1693076 | 0.88 | JAK2 (0.82) | JAK2JAK3JAK1EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011157397-A1 | HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2011-12-22 | — | — | WO | disclosed |