Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.44 |
| ▸ | PDE4A | P27815 | 9/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.44 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL728699 | 0.92 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL12081752 | 0.90 | PDE4B (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL12081829 | 0.88 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL728573 | 0.82 | PDE4B (0.60) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL730996 | 0.80 | PDE4B (0.61) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL728515 | 0.79 | PDE4B (0.68) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL730847 | 0.79 | PDE4B (0.59) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3675674 | 0.75 | PDE4B (0.82) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL12053147 | 0.75 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL3670633 | 0.71 | PDE4B (0.74) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258154-B2 | Bicyclic heteroaryl inhibitors of PDE4 | KALYPSYS INC. (US) | 2012-09-04 | — | — | US | disclosed |