Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.59 |
| ▸ | CDK1 | P06493 | 1/20 | 0.59 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CDK7 | P50613 | 1/20 | 0.59 |
| ▸ | CDK9 | P50750 | 1/20 | 0.59 |
| ▸ | CCNH | P51946 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | PAK4 | O96013 | 4/20 | 0.58 |
| ▸ | SYK | P43405 | 3/20 | 0.58 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.54 |
| ▸ | JAK3 | P52333 | 10/20 | 0.51 |
| ▸ | BTK | Q06187 | 8/20 | 0.51 |
| ▸ | MERTK | Q12866 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12085285 | 0.96 | PAK4 (0.60) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL12085309 | 0.86 | IRAK4 (0.59) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL13048674 | 0.84 | CDK2 (0.60) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL1068268 | 0.83 | SYK (0.50) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL12085438 | 0.83 | SYK (0.57) | CCNT1CDK1CCNB1CDK2CDK7 | |
| SCHEMBL1017765 | 0.83 | SYK (0.58) | PAK4SYKIRAK4JAK3BTK | |
| SCHEMBL14547888 | 0.83 | SYK (0.62) | PAK4SYKIRAK4JAK3BTK | |
| SCHEMBL12085366 | 0.82 | JAK3 (0.57) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL14666824 | 0.82 | PAK4 (0.55) | PAK4IRAK4JAK3BTKMERTK | |
| SCHEMBL12085425 | 0.81 | MERTK (0.66) | PAK4IRAK4JAK3BTKMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130029944-A1 | INHIBITORS OF PROTEIN KINASES | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-01-31 | — | — | US | disclosed |
| US-8258144-B2 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20090298823-A1 | Inhibitors of protein kinases | PORTOLA PHARMACEUTICALS, INC. (US) | 2009-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130029944-A1 | INHIBITORS OF PROTEIN KINASES | SYK, BTK, JAK2 | CCNT1 1565/4885CDK1 275/4885CCNB1 1818/4885 |
| US-20090298823-A1 | Inhibitors of protein kinases | SYK, BTK, JAK2 | CCNT1 1565/4885CDK1 275/4885CCNB1 1818/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.