Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.70 |
| ▸ | LMNA | P02545 | 4/20 | 0.70 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.70 |
| ▸ | PGR | P06401 | 4/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.70 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | CNR1 | P21554 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
| ▸ | USP2 | O75604 | 1/20 | 0.67 |
| ▸ | TNF | P01375 | 3/20 | 0.66 |
| ▸ | IKBKB | O14920 | 2/20 | 0.66 |
| ▸ | JAK2 | O60674 | 2/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.66 |
| ▸ | PRKCA | P17252 | 2/20 | 0.66 |
| ▸ | PRKACA | P17612 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.66 |
| ▸ | JAK1 | P23458 | 2/20 | 0.66 |
| ▸ | PRKCH | P24723 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13659978 | 0.93 | HIF1A (0.68) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13659970 | 0.93 | HIF1A (0.71) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13655925 | 0.92 | HIF1A (0.66) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL1535419 | 0.90 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL21790141 | 0.90 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL23207755 | 0.89 | HIF1A (0.75) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL12087285 | 0.88 | HIF1A (0.66) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL12087280 | 0.88 | HIF1A (0.66) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL13659963 | 0.88 | HIF1A (0.68) | HIF1ALMNANR3C1PGRCYP3A4 | |
| SCHEMBL12087295 | 0.88 | HIF1A (0.84) | HIF1ALMNANR3C1PGRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940863-B1 | NITROOXY DERIVATIVES OF GLUCOCORTICOIDS | NICOX SA (FR) | 2012-09-05 | — | — | EP | disclosed |