Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | PIM2 | Q9P1W9 | 18/20 | 0.69 |
| ▸ | PIM3 | Q86V86 | 18/20 | 0.69 |
| ▸ | PIM1 | P11309 | 17/20 | 0.69 |
| ▸ | GSK3B | P49841 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12079260 | 0.87 | CYP3A4 (0.78) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12080220 | 0.87 | PIM2 (0.69) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12092822 | 0.86 | PIM2 (0.82) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12079301 | 0.86 | PIM2 (0.82) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12079877 | 0.85 | CYP3A4 (0.53) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12080691 | 0.85 | PIM2 (0.71) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12080756 | 0.84 | PIM2 (0.78) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12081144 | 0.84 | CYP3A4 (0.64) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12080232 | 0.84 | PIM2 (0.74) | CYP3A4CYP2D6CYP2C9PIM2PIM3 | |
| SCHEMBL12080740 | 0.84 | PIM2 (0.81) | CYP3A4CYP2D6CYP2C9PIM2PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120225061-A1 | TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS | NOVARTIS VACCINES AND DIAGNOSTICS, INC. | 2012-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225061-A1 | TETRASUBSTITUTED CYCLOHEXYL COMPOUNDS AS KINASE INHIBITORS | PIM1, PIM2, PIM3 | CYP3A4 1066/4885CYP2D6 1610/4885CYP2C9 1936/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.