SCHEMBL12101397 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	F10	P00742	5/20	0.44

▸	CFTR	P13569	1/20	0.43

▸	EPHX2	P34913	1/20	0.41

▸	KMT2A	Q03164	2/20	0.41

▸	NPC1	O15118	1/20	0.41

▸	RAB9A	P51151	1/20	0.41

▸	MEN1	O00255	1/20	0.41

▸	GAA	P10253	1/20	0.41

▸	LHCGR	P22888	2/20	0.40

▸	TSHR	P16473	2/20	0.40

▸	CYP2C8	P10632	1/20	0.39

▸	CYP2C9	P11712	1/20	0.39

▸	KCNH2	Q12809	1/20	0.39

▸	CCR1	P32246	2/20	0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL13104206	1.00	F10 (0.44)	F10CFTREPHX2KMT2ANPC1
SCHEMBL12371473	0.98	F10 (0.46)	F10CFTREPHX2KMT2ALHCGR
SCHEMBL13104224	0.87	F10 (0.46)	F10KMT2ANPC1RAB9AMEN1
SCHEMBL8224896	0.87	F10 (0.46)	F10KMT2ANPC1RAB9AMEN1
SCHEMBL13104152	0.87	F10 (0.52)	F10CFTRKMT2AMEN1GAA
SCHEMBL12101291	0.87	F10 (0.52)	F10CFTRKMT2AMEN1GAA
SCHEMBL12101293	0.85	F10 (0.53)	F10KMT2AMEN1GAATSHR
SCHEMBL15436018	0.84	F10 (0.48)	F10KMT2ANPC1RAB9AMEN1
SCHEMBL8471226	0.84	F10 (0.54)	F10KMT2AMEN1GAATSHR
SCHEMBL12371451	0.84	F10 (0.48)	F10KMT2ANPC1RAB9AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2051975-B1	SUBSTITUTED PROLINAMIDES, PRODUCTION THEREOF AND THEIR USE AS DRUGS	BOEHRINGER INGELHEIM INT (DE)	2012-09-12	—	—	EP	disclosed