Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 5/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.43 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | JAK2 | O60674 | 4/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.40 |
| ▸ | JAK3 | P52333 | 4/20 | 0.40 |
| ▸ | JAK1 | P23458 | 3/20 | 0.40 |
| ▸ | TYK2 | P29597 | 3/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12105285 | 0.89 | AURKA (0.41) | AURKAAURKBAURKCJAK2NTRK1 | |
| SCHEMBL12105282 | 0.88 | JAK2 (0.39) | AURKAAURKBJAK2NTRK1PAK4 | |
| SCHEMBL12102601 | 0.88 | AURKA (0.47) | AURKAAURKBAURKCJAK2NTRK1 | |
| SCHEMBL12105197 | 0.88 | AURKA (0.40) | AURKAAURKBAURKCJAK2NTRK1 | |
| SCHEMBL12105172 | 0.87 | JAK2 (0.39) | AURKAAURKBAURKCJAK2NTRK1 | |
| SCHEMBL12102451 | 0.86 | AURKA (0.60) | AURKAAURKBAURKC | |
| SCHEMBL12102479 | 0.86 | AURKA (0.45) | AURKAAURKBAURKCJAK2NTRK1 | |
| SCHEMBL12102612 | 0.86 | AURKA (0.42) | AURKAAURKBAURKCJAK2NTRK1 | |
| SCHEMBL12105304 | 0.85 | NTRK1 (0.43) | AURKAAURKBJAK2NTRK1JAK3 | |
| SCHEMBL12102430 | 0.85 | NTRK1 (0.43) | AURKAAURKBJAK2NTRK1PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110269740-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION | 2011-11-03 | — | — | US | disclosed |
| US-20110269740-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION | 2011-11-03 | — | — | US | disclosed |
| WO-2010002472-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110269740-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | JAK2, JAK1, JAK3 | AURKA 601/4885AURKB 507/4885AURKC 393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.