Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.44 |
| ▸ | MTOR | P42345 | 10/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.40 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1309917 | 0.86 | PIK3CA (0.40) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL3418876 | 0.80 | PIK3CA (0.41) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL12110507 | 0.79 | PIK3CA (0.46) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL3418867 | 0.77 | PIK3CA (0.43) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1311249 | 0.76 | MTOR (0.59) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL4439676 | 0.73 | PIK3CA (0.80) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1309975 | 0.72 | PIK3CA (0.49) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1310436 | 0.72 | PIK3CA (0.59) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL3422884 | 0.71 | PIK3CA (0.40) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1310504 | 0.70 | PIK3CA (0.62) | PIK3CAMTORPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8921361-B2 | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes | UNIVERSITY OF BASEL (CH) | 2014-12-30 | — | — | US | disclosed |
| US-20110275762-A1 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275762-A1 | TRIAZINE, PYRIMIDINE AND PYRIDINE ANALOGS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | MTOR, PIK3CA, PIK3CD | PIK3CA 2/4885MTOR 1/4885PIK3CB 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.