Dapitant

Dapitant

SCHEMBL121135

COc1ccccc1[C@H](C)C(=O)N1C[C@@H]2[C@H](C1)C(c1ccccc1)(c1ccccc1)CC[C@@]2(O)c1ccccc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 5/20 1.00
FNTA P49354 6/20 0.42
FNTB P49356 6/20 0.42
MEN1 O00255 1/20 0.40
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
TSHR P16473 1/20 0.40
CYP2C19 P33261 1/20 0.40
KMT2A Q03164 1/20 0.40
OPRM1 P35372 3/20 0.39
OPRD1 P41143 3/20 0.39
OPRK1 P41145 3/20 0.39
OPRL1 P41146 3/20 0.39
CHRM4 P08173 2/20 0.38
CHRM2 P08172 1/20 0.38
CHRM5 P08912 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
KDM4E B2RXH2 1/20 0.36
ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Dapitant SCHEMBL6437147 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
Dapitant SCHEMBL14071561 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
Dapitant SCHEMBL7582571 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
Dapitant SCHEMBL13575759 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
Dapitant SCHEMBL30695498 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
Dapitant SCHEMBL6908668 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
Dapitant SCHEMBL7768046 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
Dapitant SCHEMBL8543936 1.00 TACR1 (1.00) TACR1FNTAFNTBMEN1CYP3A4
SCHEMBL8543712 0.94 TACR1 (0.89) TACR1FNTAFNTBMEN1CYP3A4
SCHEMBL8956844 0.94 TACR1 (0.89) TACR1FNTAFNTBMEN1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2341 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4683713-A1 DEUTERATED P2X3 MODULATORS GlaxoSmithKline Intellectual Property (No.3) Limited (GB) 2026-01-28 EP claimed
US-12419861-B2 Method for preventing and/or treating chronic traumatic encephalopathy-i EUSTRALIS PHARMACEUTICALS LIMITED (TRADING AS PRESSURA NEURO) (AU) 2025-09-23 US claimed
US-20250186427-A1 METHODS AND COMPOSITIONS FOR TREATING VASOMOTOR SYMPTOMS UNIVERSITY OF WASHINGTON 2025-06-12 US claimed
EP-3441087-B1 METHODS OF TREATING CHRONIC PAIN TEVA PHARMACEUTICALS INT GMBH (CH) 2025-02-19 EP claimed
EP-4461362-A2 NK1-ANTAGONIST COMBINATION AND METHOD FOR TREATING SYNUCLEINOPATHIES Chase Therapeutics Corporation (US) 2024-11-13 EP claimed
WO-2024194352-A1 DEUTERATED P2X3 MODULATORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2024-09-26 WO claimed
US-20240299404-A1 TREATMENT OF PRURITUS WITH P2X3 MODULATORS GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2024-09-12 US claimed
US-20240252484-A1 Methods and Compositions for Treating Vasomotor Symptoms UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION 2024-08-01 US claimed
EP-3870236-B1 NANOPARTICLE ENCAPSULATION TO TARGET G PROTEIN-COUPLED RECEPTORS IN ENDOSOMES TAKEDA PHARMACEUTICALS CO (JP) 2023-08-09 EP claimed
EP-4103564-A1 P2X3 MODULATORS Bellus Health Cough Inc. (CA) 2022-12-21 EP claimed
EP-1299100-A1 METHOD OF TREATING SYMPTOMS OF HORMONAL VARIATION, INCLUDING HOT FLASHES, USING TACHYKININ RECEPTOR ANTAGONIST THE UNIVERSITY OF ROCHESTER (US) 2003-04-09 EP claimed
WO-2003024456-A1 METHODS FOR TREATING AND PREVENTING MIGRAINES EISAI CO., LTD. (JP) 2003-03-27 WO claimed
US-6525073-B2 For achieving circadian rhythm phase-shifting effect in mammal MERCK & CO. INC. 2003-02-25 US claimed
US-20020035059-A1 Prevention or treatment of insomina with a neurokinin-1 receptor antagonist MERCK & CO., INC. 2002-03-21 US claimed
US-20020016283-A1 Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist UNIVERSITY OF ROCHESTER 2002-02-07 US claimed
WO-2001095904-A1 METHOD OF TREATING SYMPTOMS OF HORMONAL VARIATION, INCLUDING HOT FLASHES, USING TACHYKININ RECEPTOR ANTAGONIST UNIVERSITY OF ROCHESTER (US) 2001-12-20 WO claimed
US-6329401-B1 PREVENTION OR TREATMENT OF SLEEP DISORDER; BY ADMINISTERING A CNS PENETRATING NEUROKININ-1 RECEPTOR ANTAGONIST MERCK & CO., INC. 2001-12-11 US claimed
US-6274604-B1 ADMINISTERING A NEUROKININ-1 RECEPTOR ANTAGONIST TO ACHIEVE A CIRCADIAN RYTHM PHASE-SHIFTING TO IMPROVE THE QUALITY OF SLEEP MERCK & CO., INC. 2001-08-14 US claimed
US-6177450-B1 MIXTURE OF PERHYDROISOINDENE COMPOUND AND BENEZAMIDE COMPOUND AVENTIS PHARMA S.A. 2001-01-23 US claimed
US-6034105-A NEUROKININ RECEPTOR ANTAGONIST; SLEEP DISORDERS MERCK & CO., INC. (US) 2000-03-07 US claimed