Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.64 |
| ▸ | AKT1 | P31749 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 7/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | TEK | Q02763 | 4/20 | 0.50 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | CSK | P41240 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.50 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12120457 | 0.90 | SRC (0.61) | SRCAKT1KDRAURKAAURKB | |
| SCHEMBL1319122 | 0.89 | SRC (0.61) | SRCAKT1KDRAURKAAURKB | |
| SCHEMBL12120698 | 0.88 | AURKA (0.67) | SRCKDRAURKAIKBKEAURKB | |
| SCHEMBL30175068 | 0.86 | SRC (0.78) | SRCAKT1KDRAURKBABL1 | |
| SCHEMBL12436052 | 0.86 | SRC (0.78) | SRCAKT1KDRAURKBABL1 | |
| SCHEMBL30429079 | 0.86 | SRC (0.78) | SRCAKT1KDRAURKBABL1 | |
| SCHEMBL12120704 | 0.85 | SRC (0.75) | SRCKDRAURKAIKBKEAURKB | |
| SCHEMBL12120703 | 0.85 | KDR (0.54) | SRCKDRAURKAIKBKEAURKB | |
| SCHEMBL13063868 | 0.84 | SRC (0.74) | SRCAKT1ABL1RIPK2PRKD3 | |
| SCHEMBL12120715 | 0.82 | SRC (0.65) | SRCKDRAURKAIKBKEAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275651-A1 | FUSED RING HETEROARYL KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275651-A1 | FUSED RING HETEROARYL KINASE INHIBITORS | CNKSR1, MAP3K20, TTK | SRC 180/4885AKT1 57/4885KDR 837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.