Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.78 |
| ▸ | AURKA | O14965 | 3/20 | 0.78 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.78 |
| ▸ | SRC | P12931 | 11/20 | 0.65 |
| ▸ | RET | P07949 | 4/20 | 0.64 |
| ▸ | KDR | P35968 | 15/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.63 |
| ▸ | FLT1 | P17948 | 4/20 | 0.62 |
| ▸ | TEK | Q02763 | 4/20 | 0.62 |
| ▸ | KIT | P10721 | 4/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.62 |
| ▸ | LCK | P06239 | 3/20 | 0.62 |
| ▸ | CSF1R | P07333 | 3/20 | 0.62 |
| ▸ | LYN | P07948 | 3/20 | 0.62 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.62 |
| ▸ | EPHA2 | P29317 | 3/20 | 0.62 |
| ▸ | FLT3 | P36888 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12120525 | 0.90 | RET (0.67) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL15978893 | 0.89 | RET (0.62) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL12120517 | 0.88 | SRC (0.64) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL12808098 | 0.87 | AURKB (1.00) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL15978897 | 0.87 | KDR (0.60) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL1318875 | 0.87 | RET (0.77) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL29496472 | 0.87 | RET (0.77) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL24710742 | 0.87 | RET (0.69) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL24710572 | 0.86 | RET (0.68) | AURKBAURKAIKBKESRCRET | |
| SCHEMBL15678343 | 0.85 | RET (0.80) | AURKBAURKAIKBKESRCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9895373-B2 | Substituted pyrazolo[3,4-D]pyrimidines and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-02-20 | — | — | US | disclosed |
| US-20160354377-A1 | SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2016-12-08 | — | — | US | disclosed |
| US-9321772-B2 | Substituted pyrazolo[3,4-D]pyrimidines and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2016-04-26 | — | — | US | disclosed |
| US-8980899-B2 | Methods of inhibiting Ire1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-03-17 | — | — | US | disclosed |
| US-20140243357-A1 | SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF | MOUNT SINAI SCHOOL OF MEDICINE (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140121126-A1 | METHODS OF DETECTING AXL AND GAS6 IN CANCER PATIENTS | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2014-05-01 | — | — | US | disclosed |
| US-20120322814-A1 | METHODS OF INHIBITING IRE1 | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-12-20 | — | — | US | disclosed |
| US-20110275651-A1 | FUSED RING HETEROARYL KINASE INHIBITORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2011-11-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322814-A1 | METHODS OF INHIBITING IRE1 | XBP1, DNAJC10, HSPA5 | AURKB 3254/4885AURKA 4253/4885IKBKE 1112/4885 |
| US-20160354377-A1 | SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF | DPYD, TYMP, TYMS | AURKB 123/4885AURKA 455/4885IKBKE 1509/4885 |
| US-20110275651-A1 | FUSED RING HETEROARYL KINASE INHIBITORS | CNKSR1, MAP3K20, TTK | AURKB 116/4885AURKA 349/4885IKBKE 197/4885 |
| US-20140243357-A1 | SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF | DPYD, TYMP, TYMS | AURKB 123/4885AURKA 455/4885IKBKE 1509/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.