Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.80 |
| ▸ | MEN1 | O00255 | 4/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.80 |
| ▸ | LMNA | P02545 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.80 |
| ▸ | HTT | P42858 | 2/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | THRB | P10828 | 1/20 | 0.80 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.80 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.80 |
| ▸ | SIRT5 | Q9NXA8 | 5/20 | 0.45 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGAV | P06756 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12297560 | 0.70 | MEN1 (0.55) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12297687 | 0.70 | MAPT (0.59) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL19559164 | 0.69 | KMT2A (0.53) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL28911495 | 0.68 | BCL2 (0.63) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12297690 | 0.66 | KMT2A (0.48) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12297673 | 0.66 | KMT2A (0.55) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3891044 | 0.66 | MEN1 (0.55) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3891040 | 0.66 | MEN1 (0.55) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL17122108 | 0.65 | KMT2A (0.57) | MAPTMEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL12297668 | 0.65 | KMT2A (0.58) | MAPTMEN1KMT2ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2525790-B1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS INC (US) | 2020-05-27 | — | — | EP | disclosed |
| US-8883438-B2 | Method for diagnosing cell proliferation disorders having a neoactive mutation at residue 97 of isocitrate dehydrogenase 1 | AGIOS PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8883438-B2 | Method for diagnosing cell proliferation disorders having a neoactive mutation at residue 97 of isocitrate dehydrogenase 1 | AGIOS PHARMACEUTICALS, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| WO-2011050211-A2 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS, INC. (US) | 2011-04-28 | — | — | WO | disclosed |