Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7768079 | 0.80 | HRH3 (0.84) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL541669 | 0.78 | HRH3 (0.59) | HRH3HDAC8HDAC6 | |
| SCHEMBL578620 | 0.78 | HRH3 (0.59) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL6412394 | 0.78 | HRH3 (0.59) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL26026491 | 0.76 | CYP2A6 (0.56) | — | |
| SCHEMBL9333011 | 0.74 | CYP2A6 (0.54) | — | |
| SCHEMBL1813157 | 0.74 | HRH3 (0.67) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL5926009 | 0.73 | HRH3 (0.73) | HRH3HDAC8HDAC6PYCR1 | |
| SCHEMBL12680476 | 0.73 | HRH3 (1.00) | HRH3HDAC8HDAC6PYCR1 | |
| Hydrochloric Acid SCHEMBL4461628 | 0.72 | HRH3 (0.64) | HRH3HDAC8HDAC6PYCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110275615-A1 | NOVEL SUBSTITUTED AMIDES, THEIR PREPARATION AND USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-11-10 | — | — | US | disclosed |
| US-20110275615-A1 | NOVEL SUBSTITUTED AMIDES, THEIR PREPARATION AND USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2011-11-10 | — | — | US | disclosed |
| US-7956093-B2 | Substituted amides, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-07 | — | — | US | disclosed |
| US-7956093-B2 | Substituted amides, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-06-07 | — | — | US | disclosed |
| US-20080113989-A1 | For example, N-(1-Carbamoyl-1-oxo-3-phenylpropan-2-yl)-2-(E-2-(4-(1-pyrrolidinylmethyl)phenyl)ethen-1-yl)benzamide; calcium channel blockers; cardiovascular disorders; antiarthritic agents; inhibitors of enzymes, especially cysteine proteases such as calpain and cathepsins | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-05-15 | — | — | US | disclosed |
| US-20080113989-A1 | For example, N-(1-Carbamoyl-1-oxo-3-phenylpropan-2-yl)-2-(E-2-(4-(1-pyrrolidinylmethyl)phenyl)ethen-1-yl)benzamide; calcium channel blockers; cardiovascular disorders; antiarthritic agents; inhibitors of enzymes, especially cysteine proteases such as calpain and cathepsins | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2008-05-15 | — | — | US | disclosed |
| US-7276500-B2 | Calcium channel blockers; cardiovascular disorders; antiarthritic agents | ABBOTT GMBH & CO. KG (DE) | 2007-10-02 | — | — | US | disclosed |
| US-7276500-B2 | Calcium channel blockers; cardiovascular disorders; antiarthritic agents | ABBOTT GMBH & CO. KG (DE) | 2007-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110275615-A1 | NOVEL SUBSTITUTED AMIDES, THEIR PREPARATION AND USE | CBR3, CBR1, HRH4 | HRH3 5/4885HDAC8 1633/4885HDAC6 1207/4885 |
| US-20080113989-A1 | For example, N-(1-Carbamoyl-1-oxo-3-phenylpropan-2-yl)-2-(E-2-(4-(1-pyrrolidinylmethyl)phenyl)ethen-1-yl)benzamide; calcium channel blockers; cardiovascular disorders; antiarthritic agents; inhibitors of enzymes, especially cysteine proteases such as calpain and cathepsins | CAPN1, CAPNS1, CAPN2 | HRH3 4432/4885HDAC8 654/4885HDAC6 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.