Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 11/20 | 0.84 |
| ▸ | AKT2 | P31751 | 6/20 | 0.84 |
| ▸ | AKT3 | Q9Y243 | 6/20 | 0.84 |
| ▸ | PRKCA | P17252 | 3/20 | 0.84 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.84 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.84 |
| ▸ | PRKCB | P05771 | 2/20 | 0.84 |
| ▸ | PRKACA | P17612 | 2/20 | 0.84 |
| ▸ | PRKACB | P22694 | 2/20 | 0.84 |
| ▸ | PKN1 | Q16512 | 2/20 | 0.84 |
| ▸ | PRKD2 | Q9BZL6 | 2/20 | 0.84 |
| ▸ | CIT | O14578 | 1/20 | 0.84 |
| ▸ | SGK1 | O00141 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | LATS1 | O95835 | 1/20 | 0.56 |
| ▸ | PRKCG | P05129 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | PRKCH | P24723 | 1/20 | 0.56 |
| ▸ | MARK3 | P27448 | 1/20 | 0.56 |
| ▸ | PRKCI | P41743 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Afuresertib SCHEMBL187686 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL29360487 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL15020961 | 0.92 | AKT1 (1.00) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL23858298 | 0.91 | AKT1 (0.98) | AKT1AKT2AKT3PRKCAROCK1 | |
| SCHEMBL1529379 | 0.91 | AKT1 (0.86) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL29432553 | 0.91 | AKT1 (0.98) | AKT1AKT2AKT3PRKCAROCK1 | |
| Afuresertib SCHEMBL1364223 | 0.91 | AKT1 (0.98) | AKT1AKT2AKT3PRKCAROCK1 | |
| SCHEMBL1529401 | 0.89 | AKT1 (0.83) | AKT1AKT2AKT3PRKCAROCK1 | |
| SCHEMBL1529539 | 0.89 | AKT1 (0.82) | AKT1AKT2AKT3PRKCAROCK1 | |
| SCHEMBL25062435 | 0.85 | AKT1 (0.87) | AKT1AKT2AKT3PRKCAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110288142-A1 | CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride | NOVARTIS AG (CH) | 2011-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110288142-A1 | CRYSTALLINE N--5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride | PIK3CD, PIK3CA, PIK3CB | AKT1 16/4885AKT2 8/4885AKT3 14/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.