Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 20/20 | 0.60 |
| ▸ | JAK2 | O60674 | 19/20 | 0.60 |
| ▸ | JAK3 | P52333 | 19/20 | 0.60 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12147955 | 0.90 | JAK1 (0.62) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL12147957 | 0.90 | JAK1 (0.57) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1368853 | 0.88 | JAK1 (0.78) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1369362 | 0.88 | JAK1 (0.78) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL12148174 | 0.84 | JAK1 (0.70) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1369820 | 0.78 | JAK1 (0.81) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1369717 | 0.78 | JAK1 (0.81) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1368939 | 0.78 | JAK1 (0.81) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL1368850 | 0.77 | JAK1 (0.76) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL12148176 | 0.77 | JAK3 (0.56) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011144585-A1 | PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |