Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.49 |
| ▸ | JAK2 | O60674 | 14/20 | 0.49 |
| ▸ | JAK1 | P23458 | 14/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1370566 | 0.83 | JAK1 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL650819 | 0.77 | JAK3 (0.47) | JAK3JAK2JAK1SYK | |
| SCHEMBL1369994 | 0.72 | JAK1 (0.76) | JAK3JAK2JAK1 | |
| SCHEMBL12148031 | 0.71 | JAK3 (0.51) | JAK3JAK2JAK1SYK | |
| SCHEMBL16797942 | 0.71 | JAK2 (0.45) | JAK3JAK2JAK1SYK | |
| SCHEMBL18720827 | 0.70 | JAK3 (0.42) | JAK3JAK2JAK1SYK | |
| SCHEMBL1368223 | 0.67 | JAK3 (0.65) | JAK3JAK2JAK1SYK | |
| SCHEMBL18720830 | 0.67 | JAK3 (0.42) | JAK3JAK2JAK1SYK | |
| SCHEMBL1368178 | 0.66 | JAK1 (1.00) | JAK3JAK2JAK1 | |
| SCHEMBL1370779 | 0.66 | JAK1 (1.00) | JAK3JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011144585-A1 | PYRROLO [2, 3 - B] PYRAZINE - 7 - CARBOXAMIDE DERIVATIVES AND THEIR USE AS JAK AND SYK INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-11-24 | — | — | WO | disclosed |