Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 11/20 | 0.85 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.85 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.75 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.67 |
| ▸ | ALB | P02768 | 2/20 | 0.62 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.62 |
| ▸ | USP2 | O75604 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.62 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | GLI1 | P08151 | 1/20 | 0.62 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.62 |
| ▸ | NT5E | P21589 | 1/20 | 0.62 |
| ▸ | DPP4 | P27487 | 1/20 | 0.62 |
| ▸ | RORC | P51449 | 1/20 | 0.62 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.62 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.62 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.60 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17124221 | 1.00 | GPBAR1 (0.85) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| Dihydrobetulinic Acid SCHEMBL14071702 | 0.92 | GPBAR1 (1.00) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| Dihydrobetulinic Acid SCHEMBL3781854 | 0.92 | GPBAR1 (1.00) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| Dihydrobetulinic Acid SCHEMBL16512008 | 0.92 | GPBAR1 (1.00) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| Dihydrobetulinic Acid SCHEMBL14086957 | 0.92 | GPBAR1 (1.00) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| Dihydrobetulinic Acid SCHEMBL23284046 | 0.92 | GPBAR1 (1.00) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| Dihydrobetulinic Acid SCHEMBL14837675 | 0.92 | GPBAR1 (1.00) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| SCHEMBL13759954 | 0.91 | GPBAR1 (0.83) | GPBAR1PRKCDNR1H4SLC10A1ALB | |
| SCHEMBL15374776 | 0.90 | GPBAR1 (0.68) | GPBAR1PRKCDNR1H4 | |
| SCHEMBL3780915 | 0.89 | GPBAR1 (0.80) | GPBAR1PRKCDNR1H4SLC10A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139604-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20150025039-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. | 2015-01-22 | — | — | US | disclosed |
| US-20110288053-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-8022083-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20090275535-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. | 2009-11-05 | — | — | US | disclosed |
| US-7429565-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025039-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | GPBAR1 4472/4885PRKCD 1931/4885NR1H4 3359/4885 |
| US-20110288053-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | GPBAR1 4472/4885PRKCD 1931/4885NR1H4 3359/4885 |
| US-20090275535-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | GPBAR1 4472/4885PRKCD 1931/4885NR1H4 3359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.