Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 1/20 | 0.53 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 8/20 | 0.41 |
| ▸ | WNT3A | P56704 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155669 | 0.89 | STIM1 (0.54) | STIM1ORAI1NPC1RAB9ATSHR | |
| SCHEMBL12241698 | 0.78 | ABL1 (0.55) | STIM1ORAI1ABL1 | |
| SCHEMBL12156049 | 0.76 | NPC1 (0.56) | STIM1ORAI1MAPK1L3MBTL1NPC1 | |
| SCHEMBL12241699 | 0.76 | STIM1 (0.51) | STIM1ORAI1ABL1 | |
| SCHEMBL12156307 | 0.76 | ABL1 (0.53) | STIM1ORAI1NPC1RAB9ATSHR | |
| SCHEMBL12156056 | 0.75 | STIM1 (0.49) | STIM1ORAI1MAPK1NPC1RAB9A | |
| SCHEMBL12241684 | 0.75 | STIM1 (0.66) | STIM1ORAI1NPC1RAB9ATSHR | |
| SCHEMBL12241691 | 0.75 | STIM1 (0.54) | STIM1ORAI1ABL1 | |
| SCHEMBL12155965 | 0.74 | ABL1 (0.51) | STIM1ORAI1NPC1RAB9ATSHR | |
| SCHEMBL12156136 | 0.74 | STIM1 (0.51) | STIM1ORAI1MAPK1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |