Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.42 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.42 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.42 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | IL2 | P60568 | 3/20 | 0.33 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | JAK2 | O60674 | 1/20 | 0.30 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.30 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12155793 | 0.82 | STIM1 (0.48) | STIM1ORAI1ORAI2IL2BRAF | |
| SCHEMBL12241483 | 0.76 | STIM1 (0.62) | STIM1ORAI1ORAI2ATRIL2 | |
| SCHEMBL12155517 | 0.74 | STIM1 (0.53) | STIM1ORAI1ORAI2ATRIL2 | |
| SCHEMBL17244768 | 0.70 | STIM1 (0.45) | STIM1ORAI1ORAI2ATRIL2 | |
| SCHEMBL14225951 | 0.67 | STIM1 (0.56) | STIM1ORAI1ORAI2ATRIL2 | |
| SCHEMBL12155602 | 0.64 | IL2 (0.48) | STIM1ORAI1ORAI2ATRKCNH2 | |
| SCHEMBL12241471 | 0.64 | NPC1 (0.52) | STIM1ORAI1ORAI2KCNH2 | |
| SCHEMBL18253168 | 0.64 | KMT2A (0.38) | — | |
| SCHEMBL12155516 | 0.63 | ATR (0.44) | STIM1ORAI1ORAI2ATRKCNH2 | |
| SCHEMBL12241480 | 0.63 | ATR (0.45) | STIM1ORAI1ORAI2ATRKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011139489-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-11-10 | — | — | WO | disclosed |