Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1476237 | 0.88 | OGA (0.57) | TLR9TLR8TLR7OGAHRH3 | |
| SCHEMBL1742758 | 0.85 | TLR9 (0.52) | TLR9TLR8TLR7OGAHRH3 | |
| SCHEMBL1744089 | 0.85 | CNR2 (0.49) | TLR9TLR8TLR7OGAHRH3 | |
| SCHEMBL1742814 | 0.85 | HRH3 (0.52) | TLR9TLR8TLR7HRH3ACVR1 | |
| SCHEMBL1744840 | 0.85 | TLR9 (0.46) | TLR9TLR8TLR7FYNHRH3 | |
| SCHEMBL12159783 | 0.84 | FYN (0.46) | TLR8OGAFYNHRH3ALK | |
| SCHEMBL15166541 | 0.84 | TLR9 (0.55) | TLR9TLR8TLR7HRH3ACVR1 | |
| SCHEMBL1742769 | 0.83 | HRH3 (0.54) | TLR9TLR8TLR7FYNHRH3 | |
| SCHEMBL1743226 | 0.83 | ALK (0.46) | TLR9TLR8TLR7OGAFYN | |
| SCHEMBL12159833 | 0.83 | OGA (0.42) | TLR9TLR8TLR7OGAHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2386554-A1 | Compounds active at the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2011-11-16 | — | — | EP | disclosed |