Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 15/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190794 | 0.87 | PIK3CA (0.71) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL17255576 | 0.77 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL958777 | 0.76 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CGPARP1 | |
| SCHEMBL1180282 | 0.76 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGPARP1 | |
| SCHEMBL1180888 | 0.76 | PIK3CA (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGPARP1 | |
| SCHEMBL1180666 | 0.73 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL964128 | 0.72 | PIK3CA (0.75) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL12166175 | 0.72 | PIK3CA (0.57) | PIK3CAPIK3CDPIK3CBPIK3CGADORA2A | |
| SCHEMBL962251 | 0.72 | PIK3CA (0.73) | PIK3CAPIK3CDPIK3CBPIK3CG | |
| SCHEMBL960842 | 0.72 | PIK3CA (0.82) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |