Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 9/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MTOR | P42345 | 6/20 | 0.46 |
| ▸ | USP2 | O75604 | 4/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12166180 | 0.89 | PIK3CA (0.69) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12166291 | 0.87 | PIK3CA (0.54) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL10265724 | 0.82 | PIK3CA (0.79) | PIK3CAPIK3CDPIK3CBPIK3CGCYP1A2 | |
| SCHEMBL12166377 | 0.79 | ABCC4 (0.48) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12166214 | 0.76 | PIK3CA (0.56) | PIK3CAPIK3CDPIK3CBPIK3CGCYP1A2 | |
| SCHEMBL190300 | 0.72 | PIK3CA (0.80) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL12166370 | 0.72 | PIK3CA (0.59) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL190409 | 0.71 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL8212241 | 0.71 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR | |
| SCHEMBL962660 | 0.70 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |