Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | MTOR | P42345 | 2/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.43 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | PAK4 | O96013 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | FGR | P09769 | 1/20 | 0.43 |
| ▸ | FER | P16591 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TEC | P42680 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | PRKDC | P78527 | 1/20 | 0.43 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL190854 | 0.87 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL190853 | 0.87 | PIK3CA (0.60) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL4072798 | 0.74 | PIK3CA (0.53) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1180695 | 0.74 | PIK3CA (0.82) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1181496 | 0.74 | PIK3CA (0.82) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1180698 | 0.74 | PIK3CA (0.82) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL189797 | 0.73 | PIK3CA (0.63) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL190630 | 0.73 | PIK3CA (0.63) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1181130 | 0.72 | PIK3CA (0.69) | PIK3CAPIK3CBPIK3CDMTORPIK3CG | |
| SCHEMBL1181134 | 0.72 | PIK3CA (0.69) | PIK3CAPIK3CBPIK3CDMTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041139-B1 | PHARMACEUTICAL COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2011-11-09 | — | — | EP | disclosed |