Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.57 |
| ▸ | FXR2 | P51116 | 1/20 | 0.54 |
| ▸ | LIFR | P42702 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12168784 | 0.87 | NR1H4 (0.75) | NR1H4FXR2 | |
| SCHEMBL29880650 | 0.85 | NR1H4 (0.77) | NR1H4FXR2LIFR | |
| SCHEMBL1163955 | 0.85 | NR1H4 (0.77) | NR1H4FXR2LIFR | |
| SCHEMBL12168782 | 0.84 | NR1H4 (0.73) | NR1H4FXR2LIFR | |
| SCHEMBL19760095 | 0.83 | NR1H4 (0.77) | NR1H4FXR2LIFR | |
| SCHEMBL12168781 | 0.82 | NR1H4 (0.67) | NR1H4FXR2 | |
| SCHEMBL12168783 | 0.80 | NR1H4 (0.65) | NR1H4FXR2 | |
| SCHEMBL12168899 | 0.80 | NR1H4 (0.59) | NR1H4FXR2 | |
| SCHEMBL12168911 | 0.79 | NR1H4 (0.56) | NR1H4FXR2 | |
| SCHEMBL12168737 | 0.79 | NR1H4 (0.75) | NR1H4LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952042-B2 | FXR (NR1H4) binding and activity modulating compounds | PHENEX PHARMACEUTICALS AG (DE) | 2015-02-10 | — | — | US | disclosed |
| US-20120232116-A1 | NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS | PHENEX PHARMACEUTICALS AG (DE) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232116-A1 | NOVEL FXR (NR1H4) BINDING AND ACTIVITY MODULATING COMPOUNDS | NR1H4, NR1H2, NR1H3 | NR1H4 1/4885FXR2 5/4885LIFR 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.