Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.39 |
| ▸ | MELK | Q14680 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | ALKBH2 | Q6NS38 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL182134 | 0.85 | GRM5 (0.62) | GRM5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL5667534 | 0.80 | GRM5 (0.71) | GRM5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL18311264 | 0.78 | KAT6A (0.50) | MEN1NPC1RAB9AKMT2AHPGDS | |
| SCHEMBL5667022 | 0.77 | GRM5 (0.68) | GRM5MEN1NPC1RAB9AKMT2A | |
| SCHEMBL3917676 | 0.77 | GRM5 (0.64) | GRM5MKNK1GRM4 | |
| SCHEMBL30795888 | 0.77 | GRM5 (0.64) | GRM5MKNK1GRM4 | |
| SCHEMBL15945076 | 0.77 | GRM5 (0.66) | GRM5PDE10AHPGDSALKBH2GRM4 | |
| SCHEMBL30795074 | 0.76 | GRM5 (0.67) | GRM5NPC1PDE10AMKNK1GRM4 | |
| SCHEMBL3921029 | 0.76 | GRM5 (0.67) | GRM5NPC1PDE10AMKNK1GRM4 | |
| SCHEMBL3919683 | 0.76 | GRM5 (0.67) | GRM5PDE10AMKNK1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387995-A1 | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith | PTC Therapeutics, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2007117438-A2 | METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH | PTC THERAPEUTICS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |