Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.69 |
| ▸ | FAAH | O00519 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 7/20 | 0.64 |
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | MITF | O75030 | 3/20 | 0.64 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | CASP3 | P42574 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 1/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.64 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.64 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CBS | P35520 | 1/20 | 0.57 |
| ▸ | IDH1 | O75874 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6110185 | 0.86 | EPHX2 (0.91) | EPHX2FAAHNPC1RAB9AKMT2A | |
| SCHEMBL22103767 | 0.85 | EPHX2 (0.86) | EPHX2FAAHNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2105696 | 0.85 | NPC1 (0.69) | NPC1RAB9AMITFSMN1; SMN2MEN1 | |
| SCHEMBL4097097 | 0.84 | MEN1 (0.56) | EPHX2FAAHNPC1RAB9AMEN1 | |
| SCHEMBL26154100 | 0.83 | EPHX2 (0.71) | EPHX2FAAHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11555827 | 0.82 | EPHX2 (1.00) | EPHX2FAAHNPC1RAB9AMEN1 | |
| SCHEMBL26156260 | 0.82 | EPHX2 (0.69) | EPHX2FAAHNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2959925 | 0.82 | HIF1A (0.72) | NPC1RAB9AMITFPAX8SMN1; SMN2 | |
| SCHEMBL4258215 | 0.82 | EPHX2 (1.00) | EPHX2FAAHNPC1RAB9AKMT2A | |
| SCHEMBL4116664 | 0.81 | SMN1; SMN2 (0.67) | EPHX2NPC1RAB9AMITFPAX8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387995-A1 | Methods for the production of functional protein from DNA having a nonsense mutation and the treatment of disorders associated therewith | PTC Therapeutics, Inc. (US) | 2011-11-23 | — | — | EP | disclosed |
| WO-2007117438-A2 | METHODS FOR THE PRODUCTION OF FUNCTIONAL PROTEIN FROM DNA HAVING A NONSENSE MUTATION AND THE TREATMENT OF DISORDERS ASSOCIATED THEREWITH | PTC THERAPEUTICS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |