Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.45 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.45 |
| ▸ | RAF1 | P04049 | 1/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.45 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL87454 | 0.81 | CYP1A2 (0.40) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL79548 | 0.81 | CYP1A2 (0.40) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL22409625 | 0.75 | KMT2A (0.51) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL15756387 | 0.74 | MAPT (0.50) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL333756 | 0.73 | MAPT (0.56) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL29935774 | 0.73 | MAPT (0.56) | MAPTALDH1A1HPGDMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27593140 | 0.72 | MAPT (0.54) | MAPTALDH1A1HPGDMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL27545773 | 0.72 | MAPT (0.54) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL8186352 | 0.72 | MEN1 (0.41) | MAPTALDH1A1HPGDMEN1KMT2A | |
| SCHEMBL6291703 | 0.72 | PARP1 (0.47) | MAPTALDH1A1HPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012125447-A2 | PIPERAZINEDIONE COMPOUNDS | TAIPEI MEDICAL UNIVERSITY (TW) | 2012-09-20 | — | — | WO | disclosed |
| US-20120232088-A1 | PIPERAZINEDIONE COMPOUNDS | NATIONAL TAIWAN UNIVERSITY (TW) | 2012-09-13 | — | — | US | disclosed |
| US-20120232088-A1 | PIPERAZINEDIONE COMPOUNDS | NATIONAL TAIWAN UNIVERSITY (TW) | 2012-09-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232088-A1 | PIPERAZINEDIONE COMPOUNDS | ABL1, ERBB2, PAK5 | MAPT 2483/4885ALDH1A1 1572/4885HPGD 3635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.