Clonixin

Clonixin

SCHEMBL121785

Cc1c(Cl)cccc1Nc1ncccc1C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHODH Q02127 7/20 1.00
HDAC6 Q9UBN7 1/20 0.67
MEN1 O00255 5/20 0.66
KMT2A Q03164 5/20 0.66
LMNA P02545 3/20 0.66
MT-CO2 P00403 2/20 0.66
MAPT P10636 2/20 0.66
CYP1A2 P05177 2/20 0.66
HIF1A Q16665 2/20 0.66
USP2 O75604 1/20 0.66
TTR P02766 1/20 0.66
PLA2G1B P04054 1/20 0.66
PGR P06401 1/20 0.66
CYP3A4 P08684 1/20 0.66
HTR1A P08908 1/20 0.66
ADRA2A P08913 1/20 0.66
ADORA3 P0DMS8 1/20 0.66
AR P10275 1/20 0.66
CYP2C9 P11712 1/20 0.66
HPGD P15428 1/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Clonixin SCHEMBL9143637 1.00 DHODH (1.00) DHODHHDAC6MEN1KMT2ALMNA
Clonixin SCHEMBL30702579 1.00 DHODH (1.00) DHODHHDAC6MEN1KMT2ALMNA
Clonixin SCHEMBL10427935 0.90 DHODH (0.80) DHODHHDAC6MEN1KMT2ALMNA
SCHEMBL11011871 0.89 DHODH (0.81) DHODHHDAC6MEN1KMT2ALMNA
Nixylic Acid SCHEMBL2733856 0.86 DHODH (0.76) DHODHHDAC6MEN1KMT2ALMNA
Nixylic Acid SCHEMBL31016400 0.86 DHODH (0.76) DHODHHDAC6MEN1KMT2ALMNA
Diclonixin SCHEMBL432134 0.86 DHODH (0.76) DHODHHDAC6MEN1KMT2ALMNA
SCHEMBL15206804 0.86 SMN1; SMN2 (0.76) DHODHHDAC6MEN1KMT2ALMNA
Clonixin SCHEMBL29358647 0.84 DHODH (0.70) DHODHHDAC6MEN1KMT2ALMNA
Clonixin SCHEMBL2253593 0.84 DHODH (0.70) DHODHHDAC6MEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 12694 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122085399-A Ultra-low back scattering extinction device for weak light detection 2026-05-26 CN claimed
CN-116735967-B High-speed train impedance measurement method based on self-adaptive broadband voltage disturbance SOUTHWEST JIAOTONG UNIVERSITY (CN) 2026-05-26 CN claimed
CN-121834996-B Calculation method for vertical bearing capacity of ultra-deep thick-mud soft soil ultra-long pile group SHANDONG UNIVERSITY (CN) 2026-05-26 CN claimed
CN-122090019-A Accurate deviation correcting method and system for rigid body digital twin space of power distribution network based on point cloud mapping 2026-05-26 CN claimed
CN-122072326-A Method for calculating multi-dimensional image domain system matrix for MPI measurement by using system matrix based on multi-dimensional sinogram 布鲁克碧奥斯平有限两合公司 2026-05-22 CN claimed
CN-121632504-B Detection device and detection method for traction rigidity of immersed unit tube bundle 浙江大学 2026-05-19 CN claimed
CN-115689188-B Emergency scheduling optimization method and system for coal chemical production 中控技术股份有限公司 2026-05-19 CN claimed
CN-122062759-A Dynamic monitoring method for wharf backfill area based on stress measurement 南京理工大学 2026-05-19 CN claimed
CN-116698097-B Mixed parameter synchronous measurement method based on optical fiber Fabry-Perot interference microcavity 合肥工业大学 2026-05-19 CN claimed
CN-117655110-B Tubular billet perforation control method for improving longitudinal wall thickness uniformity 宝山钢铁股份有限公司 2026-05-19 CN claimed
EP-0492747-A2 Pharmaceutical preparation for topical application ROEMMERS S.A.I.C.F. (AR) 1992-07-01 EP claimed
EP-0466650-A2 Improvements in non-steroidal anti-inflammatory therapy WARNER-LAMBERT COMPANY (US) 1992-01-15 EP claimed
EP-0408496-A2 Solid dosage form for pharmaceutical substances CIBA-GEIGY AG (CH) 1991-01-16 EP claimed
EP-0105635-B1 NONIRRITATING AQUEOUS OPHTHALMIC COMPOSITIONS COMFORT FORMULATION FOR OCULAR THEREPEUTIC AGENTS ALCON LABORATORIES, INC. (US) 1990-04-04 EP claimed
US-4559343-A ANTIINFLAMMATORY AGENT WITH XANTHINE DERIVATIVE ALCON LABORATORIES, INC. (US) 1985-12-17 US claimed
EP-0152379-A2 Process for preparing pharmaceutical compositions containing unilamellar liposomes CIBA-GEIGY AG (CH) 1985-08-21 EP claimed
EP-0039051-B1 MANNICH-BASE HYDROXAMIC ACID PRODRUGS FOR THE IMPROVED BIOAVAILABILITY OF NON-STEROIDAL ANTI-INFLAMMATORY AGENTS, A PROCESS FOR PREPARING AND A PHARMACEUTICAL COMPOSITION CONTAINING THEM MERCK & CO. INC. (US) 1985-07-24 EP claimed
EP-0105635-A2 Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therepeutic agents ALCON LABORATORIES, INC. (US) 1984-04-18 EP claimed
EP-0051278-A1 Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same MERCK & CO. INC. (US) 1982-05-12 EP claimed
EP-0039051-A2 Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them MERCK & CO. INC. (US) 1981-11-04 EP claimed