Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.74 |
| ▸ | EZH1 | Q92800 | 6/20 | 0.74 |
| ▸ | EED | O75530 | 6/20 | 0.65 |
| ▸ | SUZ12 | Q15022 | 6/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.59 |
| ▸ | RBBP4 | Q09028 | 2/20 | 0.56 |
| ▸ | AEBP2 | Q6ZN18 | 2/20 | 0.56 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2592692 | 1.00 | EZH2 (0.74) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2592260 | 0.90 | EZH2 (0.84) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180083 | 0.89 | EZH2 (0.85) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2587354 | 0.87 | EZH2 (0.77) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2594913 | 0.86 | EZH2 (0.83) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL12180097 | 0.86 | EZH2 (0.89) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL29351554 | 0.86 | EZH2 (1.00) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2595868 | 0.86 | EZH2 (1.00) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2596023 | 0.85 | EZH2 (0.89) | EZH2EZH1EEDSUZ12HDAC1 | |
| SCHEMBL2594079 | 0.85 | EZH2 (0.83) | EZH2EZH1EEDSUZ12HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3246027-A1 | INDOLE DERIVATIVES FOR THE TREATMENT OF CANCER | GlaxoSmithKline LLC (US) | 2017-11-22 | — | — | EP | disclosed |
| WO-2011140324-A1 | INDOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |