Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 0.61 |
| ▸ | EZH1 | Q92800 | 8/20 | 0.61 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.52 |
| ▸ | EED | O75530 | 1/20 | 0.52 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.52 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.52 |
| ▸ | RBBP7 | Q16576 | 1/20 | 0.52 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.52 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2594868 | 0.90 | EZH2 (0.76) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL12180881 | 0.88 | EZH2 (0.64) | EZH2EEDRBBP4SUZ12RBBP7 | |
| SCHEMBL2592844 | 0.86 | EZH2 (0.73) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12180723 | 0.86 | EZH1 (0.65) | EZH2EZH1 | |
| SCHEMBL12180130 | 0.86 | EZH2 (0.51) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12180682 | 0.83 | EZH1 (0.66) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL12180104 | 0.83 | EZH2 (0.53) | EZH2EZH1EEDRBBP4SUZ12 | |
| SCHEMBL12180781 | 0.82 | EZH1 (0.77) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL12180803 | 0.81 | EZH1 (0.71) | EZH2EZH1PRMT3EEDRBBP4 | |
| SCHEMBL2591172 | 0.80 | EZH2 (0.64) | EZH2EZH1EEDRBBP4SUZ12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011140325-A1 | INDAZOLES | GLAXOSMITHKLINE LLC (US) | 2011-11-10 | — | — | WO | disclosed |