Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14752663 | 0.85 | PRCP (0.56) | PRCPALDH1A1SMN1; SMN2MAP3K12KDM4E | |
| SCHEMBL14749365 | 0.83 | PRCP (0.60) | PRCPALDH1A1SMN1; SMN2MAP3K12KDM4E | |
| SCHEMBL14749316 | 0.83 | PRCP (0.57) | PRCPALDH1A1SMN1; SMN2MAP3K12KDM4E | |
| SCHEMBL14749356 | 0.83 | PRCP (0.54) | PRCPALDH1A1SMN1; SMN2MAP3K12KDM4E | |
| SCHEMBL14749320 | 0.82 | PRCP (0.58) | PRCPALDH1A1SMN1; SMN2MAP3K12KDM4E | |
| SCHEMBL14752561 | 0.80 | PRCP (0.62) | PRCPALDH1A1SMN1; SMN2MAP3K12KDM4E | |
| SCHEMBL14749319 | 0.80 | PRCP (0.57) | PRCPALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL14749330 | 0.79 | PRCP (0.57) | PRCPALDH1A1SMN1; SMN2MAP3K12GRM5 | |
| SCHEMBL14749343 | 0.79 | PRCP (0.56) | PRCPALDH1A1KDM4EGRM5 | |
| SCHEMBL14749342 | 0.78 | PRCP (0.53) | PRCPALDH1A1SMN1; SMN2KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011146354-A1 | NOVEL PROLYLCARBOXYPEPTIDASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-11-24 | — | — | WO | disclosed |